منابع مشابه
Neurofibromatosis type 1: modeling CNS dysfunction.
Neurofibromatosis type 1 (NF1) is the most common monogenic disorder in which individuals manifest CNS abnormalities. Affected individuals develop glial neoplasms (optic gliomas, malignant astrocytomas) and neuronal dysfunction (learning disabilities, attention deficits). Nf1 genetically engineered mouse models have revealed the molecular and cellular underpinnings of gliomagenesis, attention d...
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BACKGROUND AND PURPOSE In a subset of in vivo MR spectra acquired from pediatric brain tumors, we have observed an unassigned peak. The goal of this study was to determine the molecule of origin, and the prevalence and concentration of this chemical in various pediatric brain tumors. MATERIALS AND METHODS Single-voxel point-resolved spectroscopy (PRESS) spectra from 85 patients with brain tum...
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Crush preparation cytology technique was used during the operative procedure for the diagnosis of 199 CNS tumors. This technique is simple, easy to perform, rapid, and inexpensive. The cytomorphologic findings were excellent and helped achieve a rapid and correct diagnosis. This technique was used on the tiny, small specimens which were not suitable for frozen sectioning. The results were c...
متن کاملGlomus tumors in individuals with neurofibromatosis type 1.
BACKGROUND Glomus tumors have recently been reported in individuals with the neurofibromatosis type 1 (NF1) cancer disposition syndrome. We compare the clinical and molecular features of these painful hamartomas in a series of sporadic and NF1-associated cases. OBJECTIVE We sought to evaluate the association of NF1 with glomus tumors and to compare NF1-associated glomus tumors with sporadic g...
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Neurofibromatosis type 1 is an autosomal dominantly inherited disease predisposing to a multitude of tumors, most characteristically benign plexiform neurofibromas and diffuse cutaneous neurofibromas. We investigated the presence and distribution of somatic mitochondrial DNA (mtDNA) mutations in neurofibromas and in nontumor tissue of neurofibromatosis type 1 patients. MtDNA alterations in the ...
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ژورنال
عنوان ژورنال: Journal of Clinical Oncology
سال: 2017
ISSN: 0732-183X,1527-7755
DOI: 10.1200/jco.2016.71.7199